20+ years of applied mycology · A division of  Crowe Logic, Inc.

The PhD-Quantized Knowledge Lake for psychedelic drug discovery.

15 Schedule I compounds with PubMed-cited pharmacology. 29 PhD-trained AI expert agents composited from real literature and federal regulation. A DEA Schedule I application drafted in two weeks, not three months.

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Built by Michael Crowe — founder of Southwest Mushrooms, author of The Mushroom Grower, principal architect of CriOS Nova and the Crowe Logic AI platform.

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The platform

A working commercial stack on top of CriOS Nova — Crowe Logic's chemoinformatics engine — and a 194-agent architecture specialized for psychedelic tryptamines, phenethylamines, ergolines, and related scaffolds.

Compound knowledge base

15 Schedule I and adjacent compounds. Each has real PubMed-cited receptor Ki values, metabolic pathways, drug interactions, toxicology, and FDA status. Queryable by target, potency, or class.

29 expert agents

24 Molecular Design specialists + 3 Psychedelic Specialists + 2 Core. Each is an AI composite persona grounded in real literature. The reasoning is PhD-grade; the disclosure is honest.

Cultivation intelligence

6 Psilocybe species and 6 commercial P. cubensis strains with peer-reviewed alkaloid profiles. Match a target profile to ranked cultivar × strain candidates with predicted dry-weight %.

Try the platform, live in your browser.

Live

No signup, no install. Everything below runs on real data from this platform. The compound browser reads the same JSON records the CLI does. The cultivar matcher uses the same scoring algorithm lfpsy cultivar-match runs server-side. The agent reveal streams previously-generated output from Dr. Nakamura and Dr. Mullen.

1 · Compound browser

Receptor profile, metabolism, FDA status

Loading compound data…
2 · Cultivar matcher

Target alkaloid profile → ranked cultivars

Pick at least one directive above to see ranked cultivars.
3 · Agent reveal

Invoke a PhD-trained AI expert agent

These are AI composite personas, not real humans. Their names are fictional. Their PhD-grade reasoning comes from grounding in real peer-reviewed literature (PubMed IDs) and federal regulation (21 CFR sections).

Sample query
Loading…
Click "Stream the response" to watch a pre-recorded CroweLM Supreme output.

Each agent's full system prompt lives in
crios_nova_psy/agents/psychedelic_specialists.yaml on GitHub.

Pricing

Three revenue surfaces. Each one buys down a specific class of regulatory or scientific friction.

Tier 1 · Subscription

Logic Foundry Psy CLI

$2,500/month

  • Full compound knowledge base access
  • 29 expert agents invocable via CLI
  • Receptor screening and selectivity profiling
  • Cultivar matching with predicted profiles
  • Unlimited queries, one named user

For preclinical discovery teams, academic labs.

Flagship

DEA Schedule I reg-pack

$25,000/application

  • 9-artifact application drafting packet
  • Cover letter, research protocol, security plan
  • 3 operational SOPs (inventory, destruction, emergency)
  • Facility diagram template + DEA Form 225 field map
  • Every artifact CFR-cited inline
  • [LEGAL REVIEW] markers flag every ambiguity

For new Schedule I applicants. Saves ~$15K + 4 weeks vs counsel-only drafting.

Tier 1 · Engagement

Cultivation consulting

$50,000/engagement

  • Facility-specific cultivation SOP
  • Cultivar selection matched to clinical endpoint
  • Contamination monitoring protocol
  • Yield and potency benchmarks from a working commercial operation
  • Includes CLI access for engagement term

For research facilities scaling for clinical supply.

Tier 2 (Q3 2026): CriOS Nova Psy API — $5K/mo per seat. Tier 3 (2027): IND-support and DEA-registered compound characterization.

Michael Crowe
Phoenix, AZ Est. 2018 Author · Operator · Architect
Founder

Michael Crowe

Founder & CEO, Crowe Logic, Inc. · Chief Mycologist

Twenty-plus years of applied mycology. Commercial operator, published author, and principal architect of the Crowe Logic AI platform — now powering Crowe Psychedelics.

  • Southwest Mushrooms — founder and operator of a working commercial cultivation business in Phoenix, AZ. Shopify retail, wholesale accounts, Google Ads acquisition, and a documented production pipeline.
  • The Mushroom Grower, Volumes 1 & 2 — published reference work on fungal cultivation, narrated across ~40 hours of audiobook production and used as the field guide by cultivators worldwide.
  • Crowe Logic AI & CriOS Nova — principal architect of the production AI platform deployed at ai.southwestmushrooms.com, the chemoinformatics engine licensed by research partners, and the 194-agent system behind this product.
  • Synapse Language & Crowe Quantum Trinity — PyPI author of synapse-lang and synapse-qubit-flow, scientific-computing DSLs for quantum chemistry and drug-discovery workflows.
  • Platform portfolio — shipping products across biotech, controlled-substance regulatory drafting, voice AI (Big O Tires, Crowe Logic voice), grants automation, and multi-agent orchestration.
"I build the operator's tools. The platform in front of you is what happens when twenty years of mycology meet twenty years of systems engineering."

Samples you can read right now

No signup. Real artifacts generated by this platform.

Agent report

Dr. Nakamura: three novel 5-HT2A agonist tryptamines

SMILES proposals, crystal-structure-guided rationale (PDB 6WHA/6WGT), predicted Ki with interpolation basis, ADMET concerns, freedom-to-operate commentary. Grounded in PMIDs 27816818, 32699011, 28129538.

12.7 KB · Markdown · via CroweLM Supreme Agent report

Dr. Mullen: Schedule I path for an Arizona biotech

Researcher vs analytical-lab choice, 21 CFR 1301 sections, realistic 8–16 week timeline, top three rejection risks with mitigations, IND scope, state-level AZ considerations. 10 CFR citations, 6 [LEGAL REVIEW] markers.

17.5 KB · Markdown · via CroweLM Supreme Reg-pack output

Complete DEA Schedule I application packet — 9 artifacts

Cover letter, research protocol summary, security plan (21 CFR 1301.71–76), three SOPs, facility diagram template, and DEA Form 225 field map. Every file watermarked DRAFT — Legal review required. Generated from a single YAML intake.

9 files · ~40 KB · via lfpsy reg-pack

Book a demo

30-minute screen-share of the CLI running on your compound of interest. Leave with a pre-populated reg-pack intake YAML and a decision on fit.

Michael Crowe

Founder and Chief Mycologist
Crowe Logic, Inc.

michael@crowelogic.com
crowelogic.com

Who we want to talk to

  • Clinical-stage psychedelic biotechs deploying AI in discovery
  • Research institutions applying for DEA Schedule I registration
  • IRB-approved protocols needing regulatory drafting
  • Commercial mycology operations scaling for clinical supply
  • DEA counsel firms offloading boilerplate drafting to clients
Book a demo →